{"id":144,"date":"2023-11-27T01:38:18","date_gmt":"2023-11-27T01:38:18","guid":{"rendered":"https:\/\/fibroblast-transfection.com\/?p=144"},"modified":"2023-05-03T01:43:28","modified_gmt":"2023-05-03T01:43:28","slug":"rough-endoplasmic-reticulum","status":"publish","type":"post","link":"https:\/\/fibroblast-transfection.com\/?p=144","title":{"rendered":"Rough Endoplasmic Reticulum"},"content":{"rendered":"\n

The rough endoplasmic reticulum (RER) is a network of membrane-bound sacs and tubules found within eukaryotic cells<\/a>. It is called “rough” because its outer surface is studded with ribosomes, which give it a textured appearance when viewed under a microscope. The RER plays a crucial role in protein synthesis, folding, and quality control, as well as the synthesis of certain lipids.<\/p>\n\n\n\n

Key functions of the rough endoplasmic reticulum include:<\/p>\n\n\n\n

    \n
  1. Protein synthesis: The ribosomes attached to the RER are the sites of protein synthesis. As the ribosomes translate mRNA into proteins, the newly synthesized polypeptide chains are threaded into the lumen of the RER, where they undergo folding and modification.<\/li>\n\n\n\n
  2. Protein folding and quality control: The RER provides an environment that facilitates protein folding and ensures that only correctly folded proteins are transported to their final destinations within the cell or secreted outside the cell. Molecular chaperones within the RER lumen assist in protein folding and prevent the aggregation of misfolded proteins.<\/li>\n\n\n\n
  3. Post-translational modifications: Proteins synthesized in the RER can undergo various post-translational modifications, such as glycosylation (the addition of carbohydrate chains) and disulfide bond formation. These modifications are essential for proper protein folding, stability, and function.<\/li>\n\n\n\n
  4. Protein sorting and transport: Proteins synthesized in the RER are either transported to other cellular compartments, such as the Golgi apparatus, or destined for secretion. The RER is involved in sorting proteins and packaging them into vesicles for transport to their appropriate destinations.<\/li>\n\n\n\n
  5. Lipid synthesis: In addition to its role in protein synthesis, the RER is involved in the synthesis of certain lipids, such as phospholipids and cholesterol. These lipids are important components of cellular membranes and contribute to membrane fluidity and function.<\/li>\n<\/ol>\n\n\n\n

    The rough endoplasmic reticulum plays a central role in the synthesis, folding, and quality control of proteins, as well as lipid synthesis. Its functions are essential for maintaining cellular homeostasis and ensuring the proper functioning of proteins within the cell.<\/p>\n","protected":false},"excerpt":{"rendered":"

    The rough endoplasmic reticulum (RER) is a network of membrane-bound sacs and tubules found within eukaryotic cells. It is called “rough” because its outer surface is studded with ribosomes, which give it a textured appearance when viewed under a microscope. The RER plays a crucial role in protein synthesis, folding, and quality control, as well … Continue reading “Rough Endoplasmic Reticulum”<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-144","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nRough Endoplasmic Reticulum<\/title>\n<meta name=\"description\" content=\"The rough endoplasmic reticulum (RER) is a network of membrane-bound sacs and tubules found within eukaryotic cells. It is called "rough"\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fibroblast-transfection.com\/?p=144\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rough Endoplasmic Reticulum\" \/>\n<meta property=\"og:description\" content=\"The rough endoplasmic reticulum (RER) is a network of membrane-bound sacs and tubules found within eukaryotic cells. It is called "rough"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fibroblast-transfection.com\/?p=144\" \/>\n<meta property=\"og:site_name\" content=\"FIBROBLAST CELLS GENERAL INFORMATION AND RESOURCES\" \/>\n<meta property=\"article:published_time\" content=\"2023-11-27T01:38:18+00:00\" \/>\n<meta name=\"author\" content=\"info\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"info\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/fibroblast-transfection.com\\\/?p=144#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fibroblast-transfection.com\\\/?p=144\"},\"author\":{\"name\":\"info\",\"@id\":\"https:\\\/\\\/fibroblast-transfection.com\\\/#\\\/schema\\\/person\\\/d74259e2de77b7ac952ab9bb3623f88a\"},\"headline\":\"Rough Endoplasmic Reticulum\",\"datePublished\":\"2023-11-27T01:38:18+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/fibroblast-transfection.com\\\/?p=144\"},\"wordCount\":322,\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/fibroblast-transfection.com\\\/?p=144\",\"url\":\"https:\\\/\\\/fibroblast-transfection.com\\\/?p=144\",\"name\":\"Rough Endoplasmic Reticulum\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fibroblast-transfection.com\\\/#website\"},\"datePublished\":\"2023-11-27T01:38:18+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/fibroblast-transfection.com\\\/#\\\/schema\\\/person\\\/d74259e2de77b7ac952ab9bb3623f88a\"},\"description\":\"The rough endoplasmic reticulum (RER) is a network of membrane-bound sacs and tubules found within eukaryotic cells. It is called \\\"rough\\\"\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/fibroblast-transfection.com\\\/?p=144#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/fibroblast-transfection.com\\\/?p=144\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/fibroblast-transfection.com\\\/?p=144#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/fibroblast-transfection.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Rough Endoplasmic Reticulum\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/fibroblast-transfection.com\\\/#website\",\"url\":\"https:\\\/\\\/fibroblast-transfection.com\\\/\",\"name\":\"FIBROBLAST CELLS GENERAL INFORMATION AND RESOURCES\",\"description\":\"Fibroblast Structure, Function and Transfection Methods Fibroblasts\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/fibroblast-transfection.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/fibroblast-transfection.com\\\/#\\\/schema\\\/person\\\/d74259e2de77b7ac952ab9bb3623f88a\",\"name\":\"info\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/7a4a825e9c3005280164be8cbe3f896df2abd133719eedf5106cbee757b67167?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/7a4a825e9c3005280164be8cbe3f896df2abd133719eedf5106cbee757b67167?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/7a4a825e9c3005280164be8cbe3f896df2abd133719eedf5106cbee757b67167?s=96&d=mm&r=g\",\"caption\":\"info\"},\"sameAs\":[\"https:\\\/\\\/fibroblast-transfection.com\"],\"url\":\"https:\\\/\\\/fibroblast-transfection.com\\\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rough Endoplasmic Reticulum","description":"The rough endoplasmic reticulum (RER) is a network of membrane-bound sacs and tubules found within eukaryotic cells. It is called \"rough\"","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fibroblast-transfection.com\/?p=144","og_locale":"en_US","og_type":"article","og_title":"Rough Endoplasmic Reticulum","og_description":"The rough endoplasmic reticulum (RER) is a network of membrane-bound sacs and tubules found within eukaryotic cells. It is called \"rough\"","og_url":"https:\/\/fibroblast-transfection.com\/?p=144","og_site_name":"FIBROBLAST CELLS GENERAL INFORMATION AND RESOURCES","article_published_time":"2023-11-27T01:38:18+00:00","author":"info","twitter_card":"summary_large_image","twitter_misc":{"Written by":"info","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/fibroblast-transfection.com\/?p=144#article","isPartOf":{"@id":"https:\/\/fibroblast-transfection.com\/?p=144"},"author":{"name":"info","@id":"https:\/\/fibroblast-transfection.com\/#\/schema\/person\/d74259e2de77b7ac952ab9bb3623f88a"},"headline":"Rough Endoplasmic Reticulum","datePublished":"2023-11-27T01:38:18+00:00","mainEntityOfPage":{"@id":"https:\/\/fibroblast-transfection.com\/?p=144"},"wordCount":322,"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/fibroblast-transfection.com\/?p=144","url":"https:\/\/fibroblast-transfection.com\/?p=144","name":"Rough Endoplasmic Reticulum","isPartOf":{"@id":"https:\/\/fibroblast-transfection.com\/#website"},"datePublished":"2023-11-27T01:38:18+00:00","author":{"@id":"https:\/\/fibroblast-transfection.com\/#\/schema\/person\/d74259e2de77b7ac952ab9bb3623f88a"},"description":"The rough endoplasmic reticulum (RER) is a network of membrane-bound sacs and tubules found within eukaryotic cells. It is called \"rough\"","breadcrumb":{"@id":"https:\/\/fibroblast-transfection.com\/?p=144#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fibroblast-transfection.com\/?p=144"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/fibroblast-transfection.com\/?p=144#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/fibroblast-transfection.com\/"},{"@type":"ListItem","position":2,"name":"Rough Endoplasmic Reticulum"}]},{"@type":"WebSite","@id":"https:\/\/fibroblast-transfection.com\/#website","url":"https:\/\/fibroblast-transfection.com\/","name":"FIBROBLAST CELLS GENERAL INFORMATION AND RESOURCES","description":"Fibroblast Structure, Function and Transfection Methods Fibroblasts","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fibroblast-transfection.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/fibroblast-transfection.com\/#\/schema\/person\/d74259e2de77b7ac952ab9bb3623f88a","name":"info","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/7a4a825e9c3005280164be8cbe3f896df2abd133719eedf5106cbee757b67167?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/7a4a825e9c3005280164be8cbe3f896df2abd133719eedf5106cbee757b67167?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7a4a825e9c3005280164be8cbe3f896df2abd133719eedf5106cbee757b67167?s=96&d=mm&r=g","caption":"info"},"sameAs":["https:\/\/fibroblast-transfection.com"],"url":"https:\/\/fibroblast-transfection.com\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/fibroblast-transfection.com\/index.php?rest_route=\/wp\/v2\/posts\/144","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fibroblast-transfection.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fibroblast-transfection.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fibroblast-transfection.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fibroblast-transfection.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=144"}],"version-history":[{"count":1,"href":"https:\/\/fibroblast-transfection.com\/index.php?rest_route=\/wp\/v2\/posts\/144\/revisions"}],"predecessor-version":[{"id":145,"href":"https:\/\/fibroblast-transfection.com\/index.php?rest_route=\/wp\/v2\/posts\/144\/revisions\/145"}],"wp:attachment":[{"href":"https:\/\/fibroblast-transfection.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=144"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fibroblast-transfection.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=144"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fibroblast-transfection.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=144"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}